Decision-Making AI For The Enterprise

InstaDeep delivers AI-powered decision-making systems for the Enterprise. With expertise in both machine intelligence research and concrete business deployments, we provide a competitive advantage to our customers in an AI-first world.

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Building AI systems for the industry

Leveraging its expertise in GPU-accelerated computing, deep learning and reinforcement learning, InstaDeep has built AI systems to tackle the most complex challenges across a range of industries and sectors.

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Enhancing Peptide Sequencing with AI

Enhancing Peptide Sequencing with AI...

on Mar 31, 2025 | 09:01am

AI is revolutionising proteomics and has the potential to unlock new frontiers in targeted healthcare and biomedical research. At the heart of this is peptide sequencing, an essen...

ProtBFN was developed to address this challenge. ProtBFN is a 650-million-parameter Bayesian Flow Network (BFN) trained on a curated dataset of 72 million biologically validated examples, optimised for generating new protein sequences.

Exploring the Proteome with ProtBFN...

on Mar 06, 2025 | 11:59am

Proteins are essential to life, driving nearly every biological process and performing critical functions in the human body—from building muscles to fighting diseases. Understan...

The AI Action Summit was an event that brought together world leaders, business experts and research luminaries as they uncovered the path ahead for the development of AI around the globe, and with the InstaDeep team being in the thick of the action throughout. Join us below as we share some of the highlights.

InstaDeep at the AI Action Summit, Grand Palais, Paris...

on Feb 20, 2025 | 11:45am

The AI Action Summit was an event that brought together world leaders, business experts and  research luminaries as they uncovered the path ahead for the development of AI around...

Research

Metalic: Meta-Learning In-Context with Protein Language Models

Jacob Beck | Shikha Surana | Manus McAuliffe | Oliver Bent | Thomas D. Barrett | Juan Jose Garau Luis | Paul Duckworth

ICLR 2025 Apr 2025
Our method, called Metalic (Meta-Learning In-Context), uses in-context learning and fine-tuning, when data is available, to adapt to new tasks.

Simple Guidance Mechanisms for Discrete Diffusion Models

Hugo Dalla-Torre | Sam Boshar | Bernardo P. de Almeida | Thomas Pierrot | Yair Schiff | Subham Sekhar Sahoo | Hao Phung | Guanghan Wang | Alexander Rush | Volodymyr Kuleshov

ICLR 2025 Apr 2025
Guidance mechanisms for discrete diffusion

De novo peptide sequencing with InstaNovo: Accurate, database-free peptide identification for large scale proteomics experiments

Kevin Eloff | Konstantinos Kalogeropoulos | Oliver Morell | Amandla Mabona | Jakob Berg Jespersen | Wesley WIlliams | Sam P. B. van Beljouw | Marcin Skwark | Andreas Hougaard Laustsen | Stan J. J. Brouns | Stan J. J. Brouns | Erwin M. Schoof | Jeroen Van Goey | Ulrich auf dem Keller | Karim Beguir | Nicolas Lopez Carranza | Timothy P. Jenkins

Nature Machine Intelligence Mar 2025

Bayesian Optimisation for Protein Sequence Design: Gaussian Processes with Zero-Shot Protein Language Model Prior Mean

Carolin Benjamins | Shikha Surana | Oliver Bent | Marius Lindauer | Paul Duckworth

NeurIPS 2024 workshop Dec 2024
Bayes Opt for Protein Design

BulkRNABert: Cancer prognosis from bulk RNA-seq based language models

Maxence Gélard | Guillaume Richard | Thomas Pierrot | Paul-Henry Cournède

ML4H 2024 Dec 2024
BulkRNABert pipeline. The 1st phase consists in pre-training the language model through masked language modeling using binned gene expressions. The 2nd phase fine-tunes a task-specific head using either cross-entropy for the classification task or a Cox-based loss for the survival task. IA3 rescaling is further added for the classification task.

BoostMD – Accelerating MD with MLIP

Lars L. Schaaf | Ilyes Batatia | Christoph Brunken | Thomas D. Barrett | Jules Tilly

NeurIPS 2024 workshop Dec 2024
Free energy surface of unseen alanine-dipeptide Comparison of the samples obtained by running ground truth MD and boostMD. The free energy of the Ramachandran plot, is directly related to the marginalized Boltzmann distribution exp [−F(ϕ, ψ)/kBT]. The reference model is evaluated every 10 steps. Both simulations are run for 5 ns (5 × 106 steps).

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